{"title":"Senolytics","description":"","products":[{"product_id":"quercetin","title":"Quercetin - Capsules - 99% Pure","description":"\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eDo you eat a whole onion every day? Probably not. Neither do we. (Pass the mints please...) All jokes aside, unless you are one of the few who can claim this unusual feat, you may not get a good amount of \u003cstrong\u003eQuercetin \u003c\/strong\u003ein your daily meals. In comes quercetin supplements to the rescue!\u003c\/span\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eQuercetin is a flavonoid polyphenol that is naturally present in fruits and vegetables such as apples, berries, grapes, onions, broccoli, and many other foods. By scavenging radical oxygen species, quercetin is an antioxidant and exhibits anti-inflammatory, anti-microbial, anti-allergic, and antiviral activity. Most recently, it became popular as a potential partner in anti-aging stacks due to its senolytic activity in \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ein vitro\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e models, which can make DNA repair more efficient. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Specifications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCapsules: 60 (250 mg \u0026amp; 500 mg), 180 (500 mg), or 300 (250 mg)\u003c\/li\u003e\n\u003cli\u003eCapsule material: HPMC (vegetable glucose)\u003c\/li\u003e\n\u003cli\u003eContents: Quercetin 99% pure\u003c\/li\u003e\n\u003cli\u003eCapsule sizes: 250 mg or 500 mg\u003c\/li\u003e\n\u003cli\u003eContainer: FSC-certified, responsibly-sourced paper tube\u003c\/li\u003e\n\u003cli\u003eContainer dimensions:\n\u003cul\u003e\n\u003cli\u003e250 mg\n\u003cul\u003e\n\u003cli\u003e\n\u003cmeta charset=\"utf-8\"\u003e60 capsules: 10 cm (height) x 5 cm (diameter)\u003c\/li\u003e\n\u003cli\u003e300 capsules: 12 cm (height) x 9 cm (diameter)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e500 mg:\n\u003cul\u003e\n\u003cli\u003e60 capsules: 10 cm (height), 5 cm (diameter)\u003c\/li\u003e\n\u003cli\u003e180 capsules: 13 cm (height), 7 cm (diameter)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003eLabels: Coated paper (faster biodegrading)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eQuercetin Benefits\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eQuercetin is a \u003cstrong\u003estrong antioxidant \u003c\/strong\u003ethat offers the body protection against oxidative stress and inflammation. \u003c\/li\u003e\n\u003cli\u003eQuercetin helps \u003cstrong\u003edecrease blood pressure\u003c\/strong\u003e and improve the symptoms of type 2 diabetes. \u003c\/li\u003e\n\u003cli\u003eQuercetin can reduce symptoms and pain of \u003cstrong\u003einflammatory conditions\u003c\/strong\u003e, such as rheumatoid arthritis.\u003c\/li\u003e\n\u003cli\u003eIn combination with other cell-stimulating drugs, quercetin has the potential to improve cell regeneration and \u003cstrong\u003eslow down aging.\u003c\/strong\u003e \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eEfficacy Studies\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eA prospective non-randomized \u003ca href=\"https:\/\/clinicaltrials.gov\/study\/NCT04946383#study-overview\"\u003eclinical study of 20-25 patients\u003c\/a\u003e, from 2022, showed that supplementation of quercetin together with dasatinib \u003cstrong\u003eslows cell proliferation\u003c\/strong\u003e and \u003cstrong\u003edecelerates aging\u003c\/strong\u003e and the risk of age-related diseases. Participants took 500 mg of quercetin and 50 mg of dasatinib oral capsules on Monday, Tuesday, and Wednesday (3 days in a row) per month for the duration of 6 months. Dasatinib is a drug that's usually used to treat certain types of leukemia.\u003c\/li\u003e\n\u003cli\u003eA study in the \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27405810\/\"\u003eJournal of the American Heart Association\u003c\/a\u003e found that supplementation of 500 mg of quercetin daily significantly \u003cstrong\u003edecreased blood pressure,\u003c\/strong\u003e especially among people with diabetes.\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34953390\/\"\u003eMultiple studies\u003c\/a\u003e have shown that quercetin acts on multiple targets of diabetes and regulates key signaling pathways, which improves the symptoms as well as the complications of \u003cstrong\u003etype 2 diabetes. \u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.nature.com\/articles\/ejcn201755\"\u003eSeveral studies\u003c\/a\u003e have found that supplementing with about 500 mg of quercetin per day helps \u003cstrong\u003elower levels of the inflammatory biomarker C-Reactive Protein\u003c\/strong\u003e (CRP), which is elevated in conditions like heart disease, rheumatoid arthritis, metabolic syndrome, and diabetes. \u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/07315724.2016.1140093\"\u003eA 2016 study\u003c\/a\u003e on 50 women with \u003cstrong\u003erheumatoid arthritis\u003c\/strong\u003e found that 500 mg of quercetin daily for eight weeks significantly helped reduce morning stiffness and pain. \u003c\/li\u003e\n\u003cli\u003e\n\u003ca href=\"https:\/\/link.springer.com\/chapter\/10.1007\/978-3-319-28383-8_12\"\u003eMany studies\u003c\/a\u003e have shown that quercetin offers \u003cstrong\u003eneuroprotective benefits\u003c\/strong\u003e, due to its ability to defend the brain against oxidative stress and inflammation.\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Augment Life","offers":[{"title":"250 mg x 60 capsules","offer_id":46874565312844,"sku":"Q30122214V2","price":13.5,"currency_code":"EUR","in_stock":true},{"title":"250 mg x 300 capsules","offer_id":47010637087052,"sku":"QC250300","price":60.0,"currency_code":"EUR","in_stock":true},{"title":"500 mg x 60 capsules","offer_id":47969691173196,"sku":"QC50060","price":27.0,"currency_code":"EUR","in_stock":true},{"title":"500 mg x 180 capsules","offer_id":48197401379148,"sku":"QC500180","price":54.0,"currency_code":"EUR","in_stock":true},{"title":"500 mg x 300 capsules","offer_id":52892259057996,"sku":"QC500300","price":90.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0554\/9821\/1374\/files\/Quercetin-60x250mg-150x70-BEG_ada70b8b-1040-4c0b-bde3-e2cc53604493.jpg?v=1748161420"},{"product_id":"fisetin-200-mg-x-120-capsules-98-pure","title":"Fisetin - 200 mg capsules - 98% Pure","description":"\u003cp\u003e\u003cstrong\u003eFisetin \u003c\/strong\u003eis a powerful flavonoid in fruits like apples, strawberries, and grapes. With its strong antioxidant properties, fisetin offers the body protection from free radicals and oxidative stress. High levels of oxidative stress damage our DNA, and can lead to the development of many neurological and metabolic diseases, as well as cancer. By protecting us from free radicals, fisetin \u003cstrong\u003ereduces inflammation\u003c\/strong\u003e and \u003cstrong\u003ecardiovascular risk\u003c\/strong\u003e and supports healthy aging, longevity, and brain health. Early research on fisetin shows its potential in anticancer therapy, as well as \u003cstrong\u003eprotection from chemotherapeutical damage\u003c\/strong\u003e. Fisetin is usually taken up in doses of 200-500 mg per day. Fisetin is considered safe, and so far, no significant side effects have been reported.\u003cstrong\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProduct Specifications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCapsules: 60 or 120\u003c\/li\u003e\n\u003cli\u003eCapsule material: HPMC (vegetable glucose)\u003c\/li\u003e\n\u003cli\u003eContents: Fisetin 98% Pure\u003c\/li\u003e\n\u003cli\u003eCapsule sizes: 200 mg\u003c\/li\u003e\n\u003cli\u003eContainer: FSC-certified, responsibly-sourced paper tube\u003c\/li\u003e\n\u003cli\u003eContainer dimensions: 120 capsules: 5,5 cm (diameter), 12 cm (height)\u003c\/li\u003e\n\u003cli\u003eLabels: Coated paper (faster biodegrading)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eBenefits\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFisetin has antioxidative and anti-inflammatory properties that can protect the body against oxidative damage and free radicals. \u003c\/li\u003e\n\u003cli\u003eFisetin's protection against free oxygen radicals supports brain health and cognitive abilities in older age. It also has the ability to reduce cellular markers of aging. \u003c\/li\u003e\n\u003cli\u003eFisetin shows a lot of potential in preclinical studies, in anticancer therapy and treating chemoresistant tumors, as well as protecting the organism from chemotherapeutic damage. \u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eEfficacy studies\u003c\/strong\u003e\u003c\/p\u003e\n\u003col\u003e\n\u003cli\u003eOne study (\u003ca href=\"https:\/\/clinicaltrials.gov\/study\/NCT04313634?intr=Fisetin\u0026amp;aggFilters=status:com\u0026amp;rank=2\u0026amp;tab=results#outcome-measures\" rel=\"noopener\" target=\"_blank\"\u003e\u003cspan\u003eNCT04313634\u003c\/span\u003e\u003c\/a\u003e\u003ca href=\"https:\/\/clinicaltrials.gov\/study\/NCT04313634?intr=Fisetin\u0026amp;aggFilters=status:com\u0026amp;rank=2\u0026amp;tab=results#outcome-measures\"\u003e\u003c\/a\u003e) examined the effects of fisetin on frailty, inflammation, and aging in older adults. It was a randomized, double-blind, placebo-controlled trial involving individuals aged 65-90. Participants took ~20 mg\/kg\/day of fisetin for three consecutive days, every 28 days, over 20 weeks. The results suggested that fisetin reduced markers of inflammation and cellular senescence, potentially improving overall health and reducing frailty in older adults. \u003c\/li\u003e\n\u003cli\u003eA pilot study called the COVFIS-HOME study (\u003ca href=\"https:\/\/clinicaltrials.gov\/study\/NCT04771611?intr=Fisetin\u0026amp;aggFilters=status:com\u0026amp;rank=1\u0026amp;tab=results\" rel=\"noopener\" target=\"_blank\"\u003eNCT04771611\u003c\/a\u003e) explored whether fisetin could reduce the severity of COVID-19 symptoms and prevent long-term complications. Participants received ~20mg\/kg \/day of oral fisetin for four days. The trial's results indicated some promise in using fisetin for these purposes, but larger studies are needed to confirm the findings.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp\u003eThere are currently no published \u003cstrong\u003eclinical trials on fisetin and cancer\u003c\/strong\u003e, but there are several ongoing ones:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFisetin is being investigated for improving the physical function in postmenopausal women after receiving chemotherapy for stage I–III breast cancer (\u003ca href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05595499\"\u003ehttps:\/\/clinicaltrials.gov\/ct2\/show\/NCT05595499\u003c\/a\u003e). \u003c\/li\u003e\n\u003cli\u003eThe efficacy, safety, and tolerability of therapies which include fisetin are being investigated in adult survivors of childhood cancer (\u003ca href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04733534\" rel=\"noopener\" target=\"_blank\"\u003ehttps:\/\/clinicaltrials.gov\/ct2\/show\/NCT04733534\u003c\/a\u003e).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003col\u003e\u003c\/ol\u003e","brand":"Augment Life","offers":[{"title":"60 capsules","offer_id":51843393814860,"sku":"FS20060","price":28.0,"currency_code":"EUR","in_stock":true},{"title":"120 capsules","offer_id":51843393782092,"sku":"FS40060","price":50.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0554\/9821\/1374\/files\/Fisetin-120x200mg-150x70-PUR.jpg?v=1729870892"}],"url":"https:\/\/augmentlifeshop.com\/collections\/senolytics.oembed","provider":"Augment Life","version":"1.0","type":"link"}