TMG (Betaine) - 500 mg x 120 capsules - Trimethylglycine, 98% Betaine

TMG stands for trimethylglycine or betaine, an amino acid naturally produced by our bodies from choline in small amounts.

TMG's role is to participate in DNA methylation and conversion of homocysteine to methionine, which is important to keep the body healthy.

High levels of homocysteine provenly increase the risk of heart disease, and taking higher doses of TMG through supplements might prevent it.

Furthermore, TMG might help fight depression. A synergy between taking nicotinamide mononucleotide (NMN) and TMG supplements for a longer and healthier lifespan has recently been proposed.

The breakdown of NMN requires high levels of methionine, and TMG supplements might help replenish them.

TMG is safe when taken in doses of up to 15 grams per day, and the most common side effects are nausea, gastrointestinal issues, and increased levels of LDL cholesterol in the body.

• TMG can convert homocysteine into methionine, a molecule necessary for the proper breakdown of NMN and energy synthesis. Taking TMG supplements with NMN supplements might ensure appropriate levels of homocysteine and NMN in the body.
• By lowering the levels of homocysteine in the organism, TMG ensures the health of the cardiovascular system, which is often damaged by high homocysteine levels. TMG could also lower blood insulin levels. 
• TMG might lower the incidence of depression and increase the efficacy of drugs used for cases of moderate depression, such as S-adenosyl-methionine. 

• A 2015 study by Pierro and Settembre showed that TMG supplementation (250 mg/day for a year) greatly improves the efficacy of the antidepressant drug S-adenosyl-methionine (Pierro and Settembre, 2015).
• A 2017 study by Gao et al. discovered that eating increased levels of betaine and choline through the diet decreased insulin resistance (Gao et al., 2017). 
• A 2021 review by Ashtary-Larky concluded that taking 4 grams of TMG per day significantly decreases the concentration of damaging homocysteine, which can be protective of heart health (Ashtary-Larky et al., 2021). 
• A 2021 study by Nobari et al. found that taking 2 grams of TMG every day for 14 weeks significantly improved sports performance (Nobari et al., 2021). However, several other studies found this not to be true. 

• Capsules: 120
• Capsule material: HPMC (vegetable glucose)
• Contents: Trimethylglycine, 98% Betaine
• Capsule size: 500 mg
• Container: glass jar
• Container dimensions: 120 capsules: 75 mm (height), 70 mm (diameter)
• Labels: Coated paper (faster biodegrading)