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Spermidine is a type of organic compound called a polyamine. It’s found naturally in foods like wheat and soybeans. As we age, polyamine levels decrease. Multiple health concerns are associated with lower levels of polyamines, but spermidine intake has been linked to delayed aging, a lower risk of death from all causes, and cognitive improvements in older adults at risk for dementia.
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Spermidine is found naturally in foods like wheat and soybeans. It’s an organic compound called a polyamine.
At the cellular level, polyamines help flush out waste and recycle damaged cells using a process known as autophagy. They also play a role in cell growth, protein synthesis, regulating the inflammatory response, and maintaining intestinal function.
As we age, the level of polyamines declines, which is associated with different health concerns.
1. Spermidine delays aging in humans
Results
Spermidine may exert specific effects on multiple organ systems engaged in cardiovascular function, anticancer immune surveillance, and neurodegeneration, thereby reducing the incidence of major age-related diseases.
Source:
Madeo et al. (2018)
Conflicts of interest
All authors are the scientific founders of Samsara Therapeutics. Didac Carmona-Gutierrez and Frank Madeo have equity interest in The Longevity Labs.
2. Higher spermidine intake is linked to lower mortality: a prospective population-based study
Results
All-cause mortality decreased with increased spermidine intake when adjusted for age, sex, and lifestyle factors. Subjects enrolled in the study in 1990 at ages ranging from 45 - 84. They were re-evaluated every 5 years through 2015. Those with the highest levels of spermidine in their diet saw the best health outcomes.
Source:
Kiechl et al. (2018)
3. The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial
Results
Subjects were given nutritional spermidine or a placebo over the course of three months in a double-blind trial. Those in the spermidine group saw moderate enhancement in memory performance and cognitive ability, The effect was not found in the placebo group.
Source:
Wirth et al. (2018)
Take 1 capsule daily with meals in the morning.
Can be taken consistently as part of a daily routine.
Do not exceed the recommended daily dose.
Each vegan capsule contains pure spermidine from wheat germ extract.
Packaged in FSC-certified, responsibly-sourced, plastic-free tubes with biodegradable labels.
60 capsule tube (3 mg or 8 mg)
Contains 60 capsules
Measures 10 cm x 5 cm
120 capsule tube (3 mg or 8 mg)
Contains 120 capsules
Measures 12 cm x 5,5 cm
This product has a carbon footprint of 259 g.
I started Augment Life after years of frustration with the supplement industry. The longevity research was clear. We know which pathways matter for healthy aging. But when I went to actually buy supplements? Everything fell short.
Products filled with fillers and additives. Labels that confused more than they clarified. Bold claims with zero proof behind them.
I wanted something simple: know exactly what I'm taking and why it works.
When I couldn't find it, I built it myself.
I partnered with longevity scientists and suppliers I could trust. We created formulations backed by clinical research and verified through independent testing. Every ingredient serves a purpose. Every formula gets tested. No proprietary blends. No shortcuts.
That's what Augment Life is today.
Supplements that actually work, proven by science, designed for people who want to live better and longer.
Because you deserve to know exactly what you're putting in your body.
—Thomas Hillard, Founder
Take one Spermidine capsule daily
Take with a meal, preferably in the morning.
Take consistently each day to support your wellness routine.
If you are pregnant, breastfeeding, or taking medication, consult a healthcare professional before use.
Spermidine is commonly included in longevity and autophagy-supporting routines. If you follow a specific fasting protocol, consider how supplements fit into your personal approach.
Spermidine is studied for its role in supporting cellular renewal processes, including autophagy. It is commonly used as part of a longevity-focused lifestyle.
Take spermidine as directed on the product label. It can be taken with or without food. Many people prefer taking it earlier in the day as part of their daily routine.
Yes. Spermidine is commonly taken daily as part of a consistent wellness routine.
Spermidine is often combined with supplements such as NMN, resveratrol, or other longevity-focused compounds. If you are taking medication or have a medical condition, consult a healthcare professional before combining supplements.
Store spermidine in a cool, dry place away from direct sunlight and moisture. Keep the container tightly closed and out of reach of children.
This article looks at the health benefits of spermidine, dosage, and potential side effects of supplementation.
This article looks at the health benefits of spermidine, dosage, and potential side effects of supplementation.
The human body's spermidine levels depend on internal production, either by cells or gut bacteria, and external sources from diet or supplementation. If you are looking to maximize the effects...
The human body's spermidine levels depend on internal production, either by cells or gut bacteria, and external sources from diet or supplementation. If you are looking to maximize the effects...
