How to Take Coenzyme Q10: Best Time, Forms, and Other Considerations

How to Take Coenzyme Q10: Best Time, Forms, and Other Considerations

Coenzyme Q10, commonly known as CoQ10, is a vital compound that plays a crucial role in cellular energy production. As a powerful antioxidant, it supports overall health and well-being.1

However, to reap its full benefits, it's essential to understand the correct way to incorporate CoQ10 into your routine. In this article, we'll explore the various forms of CoQ10, the recommended dosage, and the best practices for its intake.

1. Choose the Right Form

CoQ10 is available in two main forms – ubiquinone and ubiquinol. Ubiquinone is the oxidized form, while ubiquinol is the reduced, more readily absorbed form.2 Further research is needed to identify the optimal CoQ10 formulation.3

Tailor your choice based on your health requirements, and seek personalized advice from a healthcare professional.

2. Timing is Important

For optimal absorption, consider taking CoQ10 with a meal that contains healthy fats. Since CoQ10 is fat-soluble, consuming it alongside a meal can enhance its bioavailability.4 This simple adjustment can significantly impact the effectiveness of the supplement.

3. Keep an Eye Out for Potential Side Effects

Though side effects are uncommon and usually mild, some people have:5 

  • Digestive symptoms, such as abdominal pain, nausea, heartburn, diarrhea, and vomiting,
  • Central nervous system symptoms, such as dizziness, light sensitivity, irritability, and headache,
  • Skin itching,
  • Rash,
  • Loss of appetite,
  • Fatigue,
  • Flu-like symptoms.

4. Monitor for Potential Interactions

CoQ10 may interact with various medications, including blood thinners like warfarin, antiplatelet drugs, and certain antihypertensives. Additionally, there could be interactions with chemotherapy drugs and medications that lower blood sugar.6-7

It’s crucial to consult with your primary healthcare provider to assess in-depth potential interactions based on your individual health profile and specific medications.

5. Consider CoQ10-Rich Foods

In addition to supplementation, incorporate CoQ10-rich foods into your diet. Foods like fatty fish, organic meats, and whole grains contain CoQ10 naturally.8 A balanced diet that includes these foods can complement your CoQ10 supplementation.

Final Words

Overall, Coenzyme Q10 stands as a valuable ally in promoting cellular health and vitality. Navigating the nuances of its supplementation, from selecting the right form to getting it from whole food sources, empowers individuals to harness its full potential.

As we conclude, it's imperative to recognize the synergy between informed choices, proper dosage, and a well-rounded lifestyle. Whether you seek cardiovascular support or overall well-being, incorporating CoQ10 wisely, backed by professional guidance, sets the stage for a healthier and more energized life.

Learn more about CoQ10 and its benefits with our additional articles:

Why is CoenzymeQ10 Taken as a Supplement?



  1. Saini R. (2011). Coenzyme Q10: The essential nutrient. Journal of pharmacy & bioallied sciences, 3(3), 466–467.
  2. Molyneux, S. L., Young, J. M., Florkowski, C. M., Lever, M., & George, P. M. (2008). Coenzyme Q10: is there a clinical role and a case for measurement? The Clinical biochemist. Reviews, 29(2), 71–82.
  3. Pastor-Maldonado, C. J., Suárez-Rivero, J. M., Povea-Cabello, S., Álvarez-Córdoba, M., Villalón-García, I., Munuera-Cabeza, M., Suárez-Carrillo, A., Talaverón-Rey, M., & Sánchez-Alcázar, J. A. (2020). Coenzyme Q10: Novel Formulations and Medical Trends. International journal of molecular sciences, 21(22), 8432.
  4. Rd, J. K. M. (2023, February 14). COQ10 dosage: How much should you take per day? Healthline.
  5. Shane-McWhorter, L. (2023, December 6). Coenzyme Q10. MSD Manual Consumer Version.
  6. Mohn, E. S., Kern, H. J., Saltzman, E., Mitmesser, S. H., & McKay, D. L. (2018). Evidence of Drug-Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update. Pharmaceutics, 10(1), 36.
  7. Kanji, S., Seely, D., Yazdi, F., Tetzlaff, J., Singh, K., Tsertsvadze, A., Tricco, A. C., Sears, M. E., Ooi, T. C., Turek, M. A., Skidmore, B., & Ansari, M. T. (2012). Interactions of commonly used dietary supplements with cardiovascular drugs: a systematic review. Systematic reviews, 1, 26.
  8. Pravst, I., Zmitek, K., & Zmitek, J. (2010). Coenzyme Q10 contents in foods and fortification strategies. Critical reviews in food science and nutrition, 50(4), 269–280.
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