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Berberine is a powerful phytonutrient that has been used in Ayurvedic and Chinese medicine since 650 BC. It’s a crucial active compound that can assist in weight maintenance, promote cardiovascular health, support healthy cholesterol levels, protect the liver and kidneys, and help reduce menstrual symptoms.
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Berberine is a phytochemical found in plants like Oregon grape, phellodendron, and tree turmeric.
It’s one example of a plant alkaloid -naturally occurring organic compounds with at least one nitrogen atom. Plant alkaloid compounds like berberine can have impressive therapeutic and pharmacological effects in the body.
Berberine has low bioavailability, which is why it’s so important to supplement your diet with this powerful phytonutrient. Taking lipids (healthy fats like fish oil) at the same time you take berberine can also help with absorption.
1. The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review
Results
A meta-analysis of 12 studies found a significant reduction in body weight and BMI associated with berberine intake. Berberine may also have a positive effect on liver enzyme levels.
Source
Asbaghi et al. (2020)
2. Glucose-lowering effect of berberine on type 2 diabetes: A systematic review
Results
A meta-analysis of 37 studies showed that berberine lowers glucose in subjects with type 2 diabetes.
Source
Xie et al. (2022)
3. The clinical efficacy and safety of berberine in the treatment of non-alcoholic fatty liver disease: A systematic review
Results
A meta-analysis of 6 databases demonstrated that berberine improves liver enzymes, lipid profile, and insulin sensitivity in patients with non-alcoholic fatty liver disease.
Source
Nie et al. (2024)
4. Berberine: Ins and outs of a nature-made PCSK9 inhibitor
Results
The plant-derived compound berberine has shown anti-PCSK9 activity in several in vitro and in vivo studies that suggest it can play a beneficial role in regulating cholesterol.
Source
Ataei et al. (2022)
5. Berberine protects the liver and kidney against functional disorders and histological damages induced by ferrous sulfate
Results
This study determined that berberine protects the kidneys and liver from functional disorders caused by iron overload in rats with promising implications for future studies in human models.
Source
Gholampour et al. (2018)
6. A Single Arm Pilot Study of Effects of Berberine on the Menstrual Pattern, Ovulation Rate, Hormonal and Metabolic Profiles in Anovulatory Chinese Women with Polycystic Ovary Syndrome
Results
Of 98 subjects who were administered 1.2 g of berberine a day for four months, 14% regained regular menses. Insulin resistance and total cholesterol also decreased for the women in the study who were within a healthy BMI range.
Source
Li et al. (2015)
Take 1-3 capsules each day with meals containing carbohydrates and with lipids (healthy fats).
Do not combine with prescription glucose-lowering medications unless advised by a healthcare professional.
Consult with your physician if you are pregnant, trying to become pregnant, breast-feeding, or taking immunosuppressants. Adult use only.
Each vegan capsule contains 500 mg of certified pure Berberine powder with no additives.
Packaged in FSC-certified, responsibly-sourced, plastic-free tubes with biodegradable labels.
60 capsule tube
Contains 60 capsules
Measures 10 cm x 5 cm
180 capsule tube
Contains 180 capsules
Measures 13 cm x 7 cm
This product has a carbon footprint of 188 g.
Berberine is a plant-derived compound found in several herbs, including barberry. It has a long history of use and is widely studied for its role in supporting metabolic health.
Berberine is commonly used to support healthy glucose metabolism and insulin sensitivity. It is often taken alongside meals to help the body manage carbohydrates more efficiently.
Berberine is best taken with meals, especially meals that contain carbohydrates. Taking it with food helps improve tolerance and aligns intake with its metabolic role.
Store berberine in a cool, dry place away from direct sunlight and moisture. Keep the container tightly closed and out of reach of children.
Take berberine with meals that contain carbohydrates, ideally alongside some healthy fats. Taking berberine with food supports tolerance and aligns intake with carbohydrate metabolism.
Berberine is not a stimulant and does not provide an immediate energy boost. Its effects are related to metabolic support rather than short-term stimulation.
Most people take 1 to 3 capsules per day, depending on individual needs and tolerance. If taking more than one capsule, it is recommended to split the intake across meals.
Berberine is not recommended during pregnancy or breastfeeding. If you are taking prescription glucose-lowering medications or immunosuppressants, consult a healthcare professional before use.
Berberine is commonly used as part of a long-term wellness routine. Some people prefer to take breaks periodically, which is a personal choice.
Take 1 to 3 Berberine capsules per day
If taking more than one capsule, split the intake across meals rather than taking all capsules at once. Take each capsule with water.
Not recommended with prescription glucose-lowering medications. Adult use only.
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